All these applications require a powerful energy burst in a short period of time
Drugs 84 , 227238 (2024)
In animal models of ALS, NAC administration has been shown to decrease motor neuron loss, improve muscle mass, and increase survival time and motor performance (Andreassen 2000
Front Pharmacol 12:693983 Zhu G, Deng Y, Feng J, Li Y, Chen L, Su Y, Ping A, Wang J, Xie F, Lv L (2024) "A preliminary study of thyroid hormones and thyroid ultrasonographic images in normal Chinese rhesus monkeys (Macaca mulatta)." Ziga D, Balasubramanian S, Mehmood KT, Al-Baldawi S, Salazar GZ (2024) "Hypothyroidism and cardiovascular disease: a review." Cureus 16(1)
Since mitochondrial metabolism is prevalent in normal high-energy-demand tissues, such as the heart and liver, OXPHOS inhibitors (e.g., IACS-010759) have shown dose-limiting toxicities (DLT) in some clinical trials, hindering their widespread application [173]