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In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes

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Maternal high fat diet in lactation impacts hypothalamic neurogenesis and neurotrophic development, leading to later life susceptibility to obesity in male but not female mice