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Immune Support: Vitamin D plays a vital role in regulating immune responses, helping to prevent infections and autoimmune diseases

Stabilization of HIF-1 further upregulates the expression and activity of SREBP-1c, converting SREBP-1c from an ER precursor to an active form in the nucleus and activating transcription of genes involved in fatty acid synthesis, such as ATP citrate lyase (ACLY), acetyl-coa carboxylase (ACC), and fatty acid synthase (FASN) (72)

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Concomitantly, the increased levels of insulin reduce the binding of liver sex hormone binding globulin SHBG to testosterone, leading to hyperandrogenism (153)