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This study, the CARES trial, looked at 5000 patients, all of whom had some cardiovascular disease history, either heart attack, stroke, min-stroke or need for urgent heart surgery for coronary disease

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The SELECT trial (Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity) demonstrated that semaglutide 2.4mg actually reduced the risk of major adverse cardiovascular events by approximately 20% in people with established cardiovascular disease but without diabetes

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