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They don't increase thermogenesis, suppress appetite through GLP-1 pathways, or boost metabolic rate the way thyroid hormones or sympathomimetics do

It was originally developed in research settings to study photoprotection and as a potential treatment for conditions like erythropoietic protoporphyria, a light-sensitivity disorder

But insurance companies are not required to follow FDA labeling for coverage decisions

Niacinamides multimechanistic action (melanogenesis inhibition, melanosome transfer blockade, anti-inflammatory effects) makes it an ideal combination partner with tyrosinase inhibitors and anti-angiogenic agents

GLP-1 acts on multiple organs brain, liver, kidney, pancreasmaking it more than just an anti-obesity drug