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10.1038/361031a0 Nature 14 BouvierG.LarsenR

On the other hand, the compounds T3 and T5 display stronger tyrosinase inhibitory abilities than -arbutin and the natural compound T1 (IC 50 = 0.53 M) exhibits the greatest inhibitory potency among all, even superior to kojic acid (IC 50 = 40.69 M)

Indeed, circulating autoantibodies may detect modified forms of these antigens, potentially enhancing identification of those subjects who test negative to assay for the unmodified autoantigen (86, 134, 135)

Adverse Events Other than two occurrences of moderate bloating and three occurrences of moderate nausea, only mild symptoms were reported (see Supplementary Tables S10 and S11)

It can also disturb deep, restorative sleep