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The syndrome poses a significant clinical challenge due to its complex genetic etiology, with pathogenic mutations identified in more than 25 genes

Mechanism of Action Retatrutide works by activating three hormone receptors

In humans, the meal anticipatory rise in circulating ghrelin levels is adapted to both habitual meal patterns and the hedonic value of a meal, whereas GLP-1R agonism provides an avenue to normalize elevated brain reactivity in anticipation of palatable feeding

The issue has grown to epidemic proportions, with more than 4 million people worldwide dying each year as a result of being overweight or obese

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