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Important considerations when combining HRT and GLP-1 Before starting or combining HRT and GLP-1, there are several factors to discuss with a clinician: Not all HRT formulations are the same: Transdermal estrogen and micronized progesterone are often preferred when combining with other medications Individual risk factors matter: History of certain cancers, cardiovascular issues, or blood clots affects HRT suitability Monitoring is important: Regular check-ins help ensure both treatments are working well together Timing and dosing: A clinician can help determine whether to start treatments simultaneously or sequentially A personalized approach to weight loss during hormonal changes Because every body responds differently to hormonal shifts and medications, personalized care makes a meaningful difference in outcomes

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A review of 39 clinical studies found that IGF-1 and growth hormone administration showed increased bone resorption and bone formation