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In summary, the kinetic data for the E170X mutants support a glutaredoxin-catalysed formation of GSSEtOH as well as an exclusive interaction between Glu170 and the glutathione moiety of GSSR in accordance with the glutathione-scaffold model

doi: 10.1093/nar/27.1.29

Other common side effects include excessive water retention, headaches, nausea, or sudden blood pressure fluctuations, which are often related to inaccurate dosing or impurities in the substance

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Key Points: Life Biosciences, a biotech company co-founded by Harvards David Sinclair, received the FDAs permission to start a clinical trial of a gene therapy designed to rejuvenate dying cells