doi: 10.3389/fnins.2020.00267
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Other than saroglitazar, elafibranor, a PPAR / agonist, was tested in a 1-year phase II RCT involving 274 subjects with biopsy-proven NASH, 107 of whom were diabetic: using a modified post hoc primary endpoint, elafibranor resolved NASH in a significant percentage of patients, without worsening of fibrosis, and ameliorated the hepatic and metabolic profile [67]
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Shortly after the original identification, the copper-binding properties of GHK were recognized and the role of the copper-bound form (GHK-Cu) in many of the original activities was established