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This preservation of lean mass helps maintain metabolic rate during fat loss phases and creates more favorable body composition outcomes

However, B12 deficiency from semaglutide alone is rare in patients eating adequate protein and dairy products

Unlike other hormetic stressors, such as radiation or chemical exposure, which may carry inherent risks and require careful management, dietary hormesis involves the consumption of natural foods rich in bioactive compounds, such as fruits, vegetables, and whole grains 2,3,4

Sequences of qPCR primers can be found in Supplementary Table 1