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This is because B12 is essential for the health of the nervous system

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The studies were brief, with the first involving one of four ascending single doses over 28 days, and the second involving two or three weekly or biweekly doses over 49 days [2]

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Semaglutide may interact with Leydig cells, which express the glucagon-like peptide-1 (GLP-1) receptor and regulate GLP-1 secretion