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If oral GLP-1s demonstrate similar long-term efficacy to injectables, they could expand the total addressable market by reaching patients who would never have accepted a weekly injection

Furthermore, an increased plasma von Willebrand factor is found in hyperhomocysteinemic subjects bearing premature arterial disease (Freyburger et al, 1997) and, of major relevance, acute methionine loading induced moderate hyperhomocysteinemia results in a significant increase in von Willebrand factor (Constant et al, 1999)

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