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Functional inactivation of ANGPTL3 decreases plasma levels of TG, very low-density lipoprotein (VLDL), and low-density lipoprotein cholesterol (LDL-C) [134], while overexpression of ANGPTL3 or exogenous supplementation with its protein increases TG levels [135]

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The researchers concluded: Our findings suggest that co-administration of L-carnitine and synbiotic may be an encouraging therapeutic strategy for obesity and related cardiometabolic complications, possibly due to simultaneous targeting of multiple metabolic pathways, augmenting their bio-availability / function through potential complementary or synergistic mechanisms

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