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The mandatory 12 week washout period between cycles allows receptors to re-sensitize and return to baseline expression levels

[16] Pathogenesis [edit] Despite extensive investigation, the cause of IPF remains unknown

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Originating from ectoderm-derived neural stem cells in the neural tube, astrocyte lineage commitment begins with radial glia cells, which express classical markers such as GFAP, glutamate aspartate transporter (GLAST) and calcium-binding protein (S100B) 1