The compound's mechanism involves several physiological processes: Receptor Binding: Attaches to GHRH receptors on the pituitary gland Stimulation: Promotes endogenous GH production Feedback Regulation: Controlled by somatostatin for safety Gene Activation: Stimulates pituitary GH messenger RNA transcription A single sermorelin injection may increase GH levels for up to six hours, with repeated administrations maintaining elevated levels for up to two weeks
We, therefore, do not discard the hypothesis that the observed effects could be caused by microcrystals of uric acid, non-visualized by laser scanning confocal microscopy combined with reflection microscopy 7 or polarizing microscopy 82
Therefore, functional studies targeting pathological pathways will be necessary for further validation
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