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doi: 10.1016/j.pharmthera.2023.108488 195 Cunha-OliveiraTMontezinhoLSimesRFCarvalhoMFerreiroESilvaFS
HA-Akt, FLAG-Mdm2, GFP-Mdm2, NLSX-Mdm2 [28], C438A-Mdm2 [29], USP33, T154A-USP33 were prepared via polymerase chain reaction (PCR), and HA-Src have been described previously [30]
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This chronic, systemic depletion allows environmental toxins and latent, dormant infections (such as EBV or human herpesviruses) to reactivate and accumulate, continuously driving immune dysfunction, mast cell activation syndrome (MCAS), and unrelenting fatigue
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