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IFN- activates the JAK/STAT pathway, and TNF- activates the MAPK and NF-kB pathways, both contributing to inflammation and cell damage

Figure 18 Rendering of a discoid mitochondrion as part of an adaptive response

Effective treatments for neurological disorders are still lacking, primarily due to the presence of the blood-brain barrier (BBB), a unique and selective endothelial barrier that protects against neurotoxic substances, as well as prevents the movement of xenobiotics into the CNS, including pharmacological agents (Pardridge, 2005)

Sciences: PJBS 10, 44324437

From a systems biology point of view, the oxidative load must first be reduced before recovery becomes visible