Investigational GRA-based therapies demonstrated greater reductions in liver fat (MRI-PDFF), ALT, and enhanced liver fibrosis (ELF) scores, suggesting substantial potential for improving hepatic steatosis and fibrosis-related outcomes
Hair thinning has been reported in weight-management trials of semaglutide [10] and is discussed with tirzepatide too
GLP-1Rs are widely expressed in the whole body including the kidney [1, 10,11,12,13,14,15] and GLP-1 has diuretic and natriuretic effects in humans and animal models of hypertension, diabetes and obesity [10, 12, 13, 16]
Learn how to protect your hair while using GLP-1 medications
This approach is limited by the categorical nature of fibrosis staging, which may not fully reflect changes within stages or accurately predict clinical outcomes4, and improvements in fibrosis do not always correlate with immediate clinical outcomes, complicating the interpretation of trial results4