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The FDA uses a labeling system to provide information about the safety of drugs during pregnancy and breastfeeding

Diverticulitis is an "inflammation of irregular bulging pouches in the wall of the large intestine" that can cause severe pain, fever, nausea and changes in stool habits, according to Mayo Clinic

Thus, these metabolites may simply be an indicator of altered microbial metabolism in general, when found in excess

Regulatory Approval Regulatory bodies such as the FDA, EMA, and others evaluate clinical trial data to approve GLP-1 drugs for weight loss indications

Liver enzymes - relevant if research touches MASH (ESSENCE)