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Contact your healthcare provider promptly if you experience: Severe or persistent diarrhea : More than 68 watery stools daily, or diarrhea lasting beyond 23 days, which may lead to dehydration and electrolyte imbalances

The one signal that deserves genuine attention is the TMAO cardiovascular question a biologically plausible, observationally supported, but contested association rather than a demonstrated harm from supplementation

They have clear biological explanations, and understanding those explanations can help you decide whether to push through, adjust your approach, or stop entirely

doi: 10.1016/j.yebeh.2019.106675 [PubMed] 31774955 Kapur J, Elm J, Chamberlain JM, Barsan W, Cloyd J, Lowenstein D, Shinnar S, Conwit R, Meinzer C, Cock H, Fountain N, Connor JT, Silbergleit R