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Protective effect of sulforaphane against dopaminergic cell death

The GIP/GLP-1-receptor agonist tirzepatide was approved for the treatment of T2D by the Food and Drug Administration (FDA) in the USA for once-weekly subcutaneous injections in May 2022 and has just received a positive opinion from the European Medicines Agency (EMA)

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Harvested yeast cells were mechanically lysed by beadmilling, using a micro-minibeadbeater (Biospec), in the presence of acid-washed glass beads (500 nm diameter) and lysis buffer (RLT) provided by the Qiagen RNeasy Mini Kit

2 y Data from participants without events of interest were censored at the end of their in-trial period