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In particular, the intraperitoneal administration of K1K1 resulted in a strong neuroprotective activity on motor neurons in ALS animal models (Vallarola et al., 2020)

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doi:10.3389/fendo.2023.1026040 17

Similarly, niacinamide concentrations should not exceed 10% for periorbital use versus 15-20% sometimes used on face, and retinoids if included should be present only in gentle forms at low concentrations to avoid significant irritation

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