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In BV-2 microglia, berberine down-regulates lipopolysaccharide- or interferon--induced iNOS and cyclooxygenase-2 (COX-2) level, and inhibits inflammatory cytokines expression (for example IL-6, IL-1, TNF-) (Lu et al., 2010)

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These data demonstrate that CerS2 plays a critical role in glucose-stimulated insulin secretion (GSIS)