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Handling of dropouts or missing data For the efficacy endpoints, the last observation carried forward method was used for missing data imputation

These factors disrupt iron homeostasis by promoting hepcidin expression and inhibiting ferroportin-mediated iron export, thereby increasing intracellular free iron levels

Oxidative stress is linked to age-related conditions including cancer, high blood pressure, diabetes, and more

The siRNA sequences were inserted into the GV112 lentivirus vector containing a gcGFP fluorescent marker and sequenced to confirm the correct identity of the siRNAs

Until now, most research based on glutaminase inhibitors for cancer treatment mainly focuses on GLS1, GLS2 is considered a tumor suppressor in glioblastoma and liver cancer (Mats et al., 2018)