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Consequently, loss of FMRP results in an aberrantly increased mGluRI expression in these neurons, leading to enhanced mGluR-related long-term depression causing cognitive impairments and intellectual disability

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Enhancement in executive function: Awareness Cognition Appropriateness Eye contact Responsiveness Normalized behaviours and interaction Promotion of speech and language: Spontaneous language More complex sentences Increased vocabulary Improvements in socialization, understanding and expressing emotion: Initiation and interactive play Understanding and feeling emotions Affection and tolerance to touch Undesired effects to B12 therapy are a good sign of treatment success

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The SURMOUNT-1 trial demonstrated 20.9% mean body weight reduction with tirzepatide 15mg weekly at 72 weeks, while preclinical 5-amino-1MQ studies showed visceral fat reduction independent of caloric restriction