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The trial team is responsible for assessing and formally reporting serious adverse events to the MHRA and ethics committee as required

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An excisional biopsy was performed, and anatomopathological examination confirmed the diagnosis of lingual melanotic macula (Figure 2)

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This suggests that, to maintain weight loss, treatment for obesity should be considered chronic (as in the case of hypertension), rather than as a short course of treatment associated with acute illnesses [9, 55]