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We see gradual, progressive loss of subcutaneous fat, degradation of collagen and elastin, and a flattening of the cheeks due to loss of malar projection, all of which contribute to an aged appearance. Weight loss induced by GLP-1 medications, however, accelerates these changes
Even within the same medication, patients on identical doses can experience vastly different outcomes
Beyond that, the fat-loss benefit is small, but the amount of muscle youd lose will increase 4,5
Laboratory studies have demonstrated that GLP-1 receptor activation can reduce the production of pro-inflammatory cytokines, including tumour necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1)