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Prebiotic fibers like resistant starch need time to shift bacterial populations

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Additionally, bacteria can develop resistance mechanisms such as modifying membrane charge, producing proteases, altering metabolism, or forming biofilms, which can reduce LL-37s effectiveness

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[6] Randomized trials comparing oral and transdermal routes show broadly equivalent symptom relief but persistent route-specific differences in hepatic protein synthesis, C-reactive-protein induction, and coagulation factor expression, underscoring the need for individualized route selection