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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

References Dimet-Wiley, A., Wu, Q., Wiley, J., Eswar, A., Neelakantan, H., Savidge, T., & Watowich, S