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Furthermore, APAP exposure significantly depletes glutathione [68], suggesting that repeated exposure to the drug is potentially more hazardous than a single exposure.Although APAP metabolism is well characterized, a high degree of variability in APAP metabolism within the pediatric population has been observed, and the factors affecting this variability are poorly understood [69]

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Le glutathion peut, dans de rares cas, gnrer de l'inconfort digestif