At the molecular level, lower levels of the sealing claudins-3,5, and7 and more pore-forming claudin-2 were reported (82)
SIRT1 is also known as the "longevity gene" because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular, kidney, liver, neurodegeneration and cancer
When drugs are fast released into the body they may produce severe adverse reactions because their plasmatic concentration may reach high values in a very short time
Faster tendon healing, better collagen structure, anti-inflammatory effects, the preclinical data has real biological plausibility
Long-term safety