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Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: a five-year naturalistic study

400 In the last decades, researchers have showed that IR is an early metabolic alteration in CKD, because IR plays a primary role in metabolic syndromes characterized by abdominal obesity, high fasting glucose levels, hypertriglyceridemia, depressed serum HDL-C, and high blood pressure, that are commonly observed in CKD patients

In normal healthy tissues, FAS is expressed at very low levels

The gut-lymphatic connection is particularly important, as roughly 70% of immune cells reside in the gastrointestinal tract

It helps reduce the accumulation of triglycerides in the blood, thereby lowering the risk of cardiovascular diseases such as atherosclerosis