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Insulin resistance constitutes an important mechanistic link between prolactin abnormalities and obesity-related metabolic disorders, and is a core pathological feature of metabolic syndrome and type 2 diabetes ( A hyperglycemic clamp test showed that individuals with higher circulating prolactin levels had significantly reduced insulin sensitivity ( 4.4 Hypothalamicpituitarygonadal axis disruption The HPG axis is extremely sensitive to circulating prolactin levels