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Additional effect of metformin and celecoxib against lipid dysregulation and adipose tissue inflammation in high-fat fed rats with insulin resistance and fatty liver

Long-term studies show significant weight regain over 6-12 months of discontinuation, but a structured short break with proper weight maintenance strategies typically results in 3-8 pounds of regain, much of which is water weight and glycogen restoration that reverses quickly upon restarting medication

Use BW: Always use bacteriostatic water for reconstitution if the solution needs to be stored for more than 24-48 hours

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This is right when most people are still in the "nothing visible yet" phase, and they conclude it "doesn't work." Give it the full 8 to 12 weeks before deciding