glp-1 suicidal ideation receptor agonists and risk of suicide or suicide attempts – A nationwide cohort and self-controlled case series study Frontiers | Suicidality as a

The clinical trials that established the safety and efficacy profiles for semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) included older adults, but in numbers that were not sufficient to characterize body composition changes, functional outcomes, or long-term musculoskeletal effects specifically in adults over 65 or 75

Research of novel drug treatments for diabetes has thus moved away from insulin analogs to new peptide hormones that have similar effects, in particular the incretin hormones, such as Glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and Dipeptidyl peptidase-4 (DPP-4), a key enzyme responsible for cleaving and inactivating both of GLP-1 and GIP peptides at the penultimate alanine residue ( GLP-1 is part of the peptide growth-factor family and activates a glucagon-type seven membrane-spanning G-protein coupled receptor

Last updated on Jan 19, 2026

Habitual coffee intake and risk for nonalcoholic fatty liver disease: A two-sample mendelian randomization study

S., Schroder, E