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COVID-19 patients also display diffused white matter damage, microglial activation, and neuroinflammation at different CNS regions with olfactory neuritis (25%), nodular brainstem encephalitis (31%), and cranial nerve neuritis (6%) 199

This distinction is important because while blocking COX-2 provides the anti-inflammatory benefits, blocking COX-1 can lead to side effects like stomach problems (Daniels et al., 2016

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