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Without offering a citation for a published paper or sharing any data, Sikirics 2025 review states that this clinical trial found that the drug was safe and well-tolerated in humans

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At a BAC of around 0.40% or higher, the brain's control over essential bodily functionssuch as breathing, heartbeat, and temperature regulationbegins to shut down

A number of small studies under laboratory conditions showed that B12 can alter melatonin levels and affect circadian rhythm

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