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On the basis of variable importance in the projection (VIP) values greater than 1.0 obtained from OPLS-DA model and p values less than 0.05 acquired from Wilcoxon-Mann U test, a set of discriminating metabolites were determined

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This direct delivery method theoretically provides higher bioavailability, meaning more of the active compound reaches target tissues

Bhaskaran S, Kumar G, Thadathil N, Piekarz KM, Mohammed S, Lopez SD, Qaisar R, Walton D, Brown JL, Murphy A, Smith N, Saunders D, Beckstead MJ, Plafker S, Lewis TL Jr, Towner R, Deepa SS, Richardson A, Axtell RC, Van Remmen H (2023) Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis