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Neurogenic inflammation in acute migraine attacks is characterized by a TVS activation-induced release of neuropeptides, such as CGRP and substance P, from trigeminal nerve fibers at the dura, which causes increased vascular permeability, plasma protein extravasation, leukocyte infiltration, vasodilation, mast cell degranulation, activation of meningeal nociceptors, and the subsequent release of inflammatory mediators (5)

Docking covalent inhibitors: a parameter free approach to pose prediction and scoring

Sunal, and G

J Agric Food Chem 71:59025916

Konoplev S, Kornblau SM, Schlette E, Lu H, Thomas DA, Zhang N, Qiu YH, Coombes K, Neeley S, Kantarjian HM, Medeiros LJ, Andreeff M , Konopleva M