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Epithalamin levels decline with age, corresponding with the age-related decline in cellular regenerative capacity and melatonin production

Anyway, at higher concentrations, like those deriving from a high-fat diet, primary and secondary BAs can reduce gut barrier integrity with their detergent properties, causing increased intestinal permeability and, thus, oxidative stress, DNA damage, and production of inflammatory cytokines, such as IL-6 and TNF-alpha, which promote inflammation and cause the inactivation of the FXR, thereby powering a pro-inflammatory state in the colon [25]

Feverfew extracts show antibacterial and antifungal properties and support immune balance by calming excessive inflammation while still allowing pathogen defense

This not only helps to maintain the skins barrier function but also ensures that it remains supple and radiant

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