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For researchers choosing between the two most potent compounds in this class, retatrutide currently shows a 1.52 percentage-point weight-loss advantage over tirzepatide at comparable durations, but tirzepatide carries substantially more Phase 3 evidence and a confirmed MHRA authorisation [1][2]

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Skipping the Titration Schedule Some individuals may feel that the starting dose of 2.5 mg is too low because they dont feel immediate effects