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Moreover, Nrf2a key regulator of iron homeostasisis robustly activated by BL (Yao et al., 2020a,b), leading to increased production of NAD(P)H-dependent enzymes such as NQO1, suppression of NF-B signaling, and reduction of both -Syn aggregation and oxidative stressmediated neuroinflammatory damage (Lastres-Becker et al., 2016

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He began supplementation with 250mg of NR daily, gradually increasing to 500mg and then 750mg per day

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