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Experimental rat models of DPN have identified early metabolic abnormalities affecting nerve conduction velocities and endoneurial blood flow [89]
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INR or other appropriate coagulation tests should be monitored weekly until values stabilize and monthly thereafter in patients taking anticoagulants together with Carnitene
Conversely, hepatocytes with acquired O-GlcNAc modification exhibited reduced necroptosis and liver fibrosis, indicating that OGT has the potential to inhibit necroptosis in hepatocytes and suppress the advancement of liver fibrosis
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