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In the Boyden chamber assay, TB4 stimulated keratinocyte migration 23-fold over medium alone after just 45 hours, with as little as 10 pg of TB4 sufficient to produce a potent stimulatory response

However, a recently published case report showed that the condition of a 59-year-old woman who was previously confirmed to have MC by colonoscopy and biopsy was resolved after the patient began intravenous immunoglobulin administration despite continuing to take anthraquinone laxatives.43 However, the specific mechanism and long-term clinical effects are still unclear, and this approach may be a new method to treat MC in the future

This offers a promising mechanism by which GLP-1RAs may exert effects on compulsive intake and relapse behavior in SUDs

This mechanism is particularly beneficial for patients struggling with after-meal hyperglycemia