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Both studies demonstrated that FSP1 acts as an NADH/NADPH-dependent CoQ 10 reductase that predominantly localizes to the plasma membrane via N-terminal myristoylationa posttranslational modification essential for its antiferroptotic activity

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Mitochondria play a dual role in TLR signaling, acting as both initiators and enhancers of TLR signaling via through the release of mtDNA and mROS, as well as key intermediates in TLR signaling transduction

Together, they create a hormonal environment that strongly favors fat oxidation over fat storage