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5,6 Globally, GI disorders such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), gastroesophageal reflux disease (GERD), constipation, dyspepsia, and peptic ulcers represent a major health burden

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Most side effects are reversible upon discontinuation of therapy, but serious reactions necessitate prompt evaluation and supportive care

Pro tip: store in the fridge for a cooling de-puffing effect in the morning

Depigmentation and/or subcutaneous atrophy can occur in thin patients, especially those with dark skins, and they should be informed of this before giving consent