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NAC acts as a mucolytic (thins mucus), supports liver detoxification through pathways independent of glutathione, has studied benefits for mental health conditions, and may support hormonal balance in PCOS

The neuroprotective effect of metformin is mostly mediated by AMPK which attenuates aggregation of A and tau protein hyperphosphorylation

To further examine the effects of serine synthesis on Np63-mediated carboplatin resistance in vivo, we generated xenograft models by subcutaneously injecting transfected LUSC cells into nude mice, followed by treatment with carboplatin and/or NCT-503, an inhibitor of PHGDH (Fig

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Clin Exp Med 10(2):9398 Patan S, Munn LL, Jain RK (1996) Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis