The standard recommendation is to start tirzepatide at 2.5 mg regardless of your previous semaglutide dose
[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Jia M., Lv X., Zhu T., Shen J.C., Liu W.X., Yang J.J
Patients with pre-existing vascular risk factorsincluding hypertension, dyslipidemia, and diabetic retinopathymay be particularly susceptible
Overall, about one in five (22%) adults who are not currently taking GLP-1 drugs (88% of the public) say they would be interested in taking a GLP-1 drug to lose weight, including just 7% who say they would be very interested. This rises to four in ten (43%) among adults who are not currently taking a GLP-1 but report being diagnosed as overweight or obese in the past five years, and about one in four (27%) among those who say they have been diagnosed with diabetes or heart disease
It also appeared linked to increased pituitary RNA and GH mRNA levels, suggesting a possible expansion of somatotroph cells
