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176 Collectively, these advances underscore a fundamental conceptual shift: proteostasis must now be viewed not as a collection of isolated degradation mechanisms but as a coherent, adaptive, and deeply integrated cellular defense network whose resilience determines disease trajectory

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While its less bioavailable for musculoskeletal recovery, it has shown significant protective effects in the GI tract

Methylcobalamin injections are often recommended for these patients because they bypass the digestive system and deliver B12 directly into the bloodstream

Treatment with the non-essential metals resulted in both enrichment and depletion of cells lacking membrane transporters, as suggested by the enrichment or depletion of the respective sgRNAs, implying that some transporters were increasing, and others decreasing, the toxicity of the three metals (Fig 2BD, Table 1)